The wine industry faces significant risks climate change, such that the security of future production is under threat. To address this risk, in this paper, a framework is proposed to examine responses to climate change in the wine industry. Building upon the literature and relying on expert input, the framework takes into consideration mitigative and adaptive actions across market-based, regulatory/standards-based, and operational-based levels. To explore the framework, a case study is developed for Treasury Wine Estates (TWE), one of the world’s largest wine producers. The case study reveals verification of the framework, with TWE relying on several technologies and unique processes to engage in many mitigative and adaptive actions across the proposed levels. The findings suggest several opportunities for future study.